Resources # Antibody Reactomics in Practice Methodology, peer-reviewed evidence, and applications for scientists interested in adding antibody reactome profiling to their next big discovery. ## Featured Resources [ ![](https://cdn.sanity.io/images/vbcbvda6/production/d789ad5a7e0a909e5a212ab947adc6aefa3d99c8-1200x750.webp) White Paper ### Unbiased analysis of antibody responses to all human viruses using Infinity Bio's VirSIGHT library A peer-reviewed methodology white paper for VirSIGHT, Infinity Bio's unbiased antibody reactome assay covering 500+ human viruses from a single serum or CSF sample. Includes analytical validation (100% sensitivity against SARS-CoV-2, HIV-1, HSV1 reference cohorts), reproducibility across 6× replicate runs, and head-to-head benchmarking against PhIP-Seq on identical peptide sequences. Read white paper ](/resources/unbiased-analysis-of-antibody-responses-to-all-human-viruses-using-infinity-bios)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/df6062d9a45026fd7525f846ef6c3f9c3f11fafb-1376x768.webp) Brochure ### Antibody Reactomics: The Responsive Layer of Immune Memory Where the antibody reactome fits in the multi-omic stack, how MIPSA deciphers it, and what the HuSIGHT, VirSIGHT, and EnviroSIGHT libraries cover. Download brochure ](/resources/antibody-reactomics-overview)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/257430cd1699782d6d265a15eff4a7e3dbfa6411-1200x750.webp) Webinar ### Antibody Reactome Profiling for Human Health Why reactome profiling captures biology that other immune assays miss. Watch webinar ](/resources/antibody-reactome-profiling-for-human-health) ## Browse the full library 45 [ ![](https://cdn.sanity.io/images/vbcbvda6/production/257430cd1699782d6d265a15eff4a7e3dbfa6411-1200x750.webp) Webinar MIPSA ### Antibody Reactome Profiling for Human Health Why reactome profiling captures biology that other immune assays miss. Watch webinar ](/resources/antibody-reactome-profiling-for-human-health)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bb6af58b427851e9598c7afd982efa8cdff6c027-1200x750.webp) Video MIPSA ### How measuring the reactivities of circulating antibodies through reactome profiling can provide novel insights into human health Why reactome profiling captures biology that other immune assays miss. Watch video ](/resources/how-measuring-the-reactivities-of-circulating-antibodies-through-reactome-profil)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/aa97363ccf2216d6365cdd27c5aaefcc489db819-1200x750.webp) Brochure EnviroSIGHT HuSIGHT ### HuSIGHT and EnviroSIGHT — InSIGHTs for Parkinson's Disease HuSIGHT + EnviroSIGHT for Parkinson's research: environmental triggers and autoimmune contributions in one assay. Download brochure ](/resources/husight-and-envirosight-insights-for-parkinsons-disease)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/587a57598a7a23d6362e3069be9d146cf7cd7165-1200x750.webp) Video MIPSA ### Unveiling the Antibody Reactome: A New Frontier in Precision Immunology Antibody Reactomics: the new dimension for precision immunology research. Watch video ](/resources/unveiling-the-antibody-reactome-a-new-frontier-in-precision-immunology)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/23ee91109f097e24ae7768725bfc72948a8879b1-1200x750.webp) Podcast MIPSA ### Antibody Reactome Profiling via self-assembling libraries of DNA barcoded antigens — AIRRC7 Ben Larman at AIRRC7: the science behind MIPSA library construction. Listen to podcast ](/resources/antibody-reactome-profiling-via-self-assembling-libraries-of-dna-barcoded-antige)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/243b92ec85d41a21e0e8f829b4a024e53b85efd1-1200x750.webp) Video MIPSA ### Infinity Bio MIPSA Explainer How MIPSA deciphers the antibody reactome: the three-step workflow at a glance. Watch video ](/resources/infinity-bio-mipsa-explainer)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/d789ad5a7e0a909e5a212ab947adc6aefa3d99c8-1200x750.webp) White Paper VirSIGHT Infectious Disease ### Unbiased analysis of antibody responses to all human viruses using Infinity Bio's VirSIGHT library A peer-reviewed methodology white paper for VirSIGHT, Infinity Bio's unbiased antibody reactome assay covering 500+ human viruses from a single serum or CSF sample. Includes analytical validation (100% sensitivity against SARS-CoV-2, HIV-1, HSV1 reference cohorts), reproducibility across 6× replicate runs, and head-to-head benchmarking against PhIP-Seq on identical peptide sequences. Read white paper ](/resources/unbiased-analysis-of-antibody-responses-to-all-human-viruses-using-infinity-bios)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/42d91c8dac09c5fcb1af7609488897b8e4f36e5a-1200x750.webp) Brochure VirSIGHT Infectious Disease ### VirSIGHT InSIGHTs VirSIGHT at a glance: antibody reactome profiling across the known human virome (500+ species). Download brochure ](/resources/virsight-insights)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/df6062d9a45026fd7525f846ef6c3f9c3f11fafb-1376x768.webp) Brochure MIPSA VirSIGHT 2026 ### Antibody Reactomics: The Responsive Layer of Immune Memory Where the antibody reactome fits in the multi-omic stack, how MIPSA deciphers it, and what the HuSIGHT, VirSIGHT, and EnviroSIGHT libraries cover. Download brochure ](/resources/antibody-reactomics-overview)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Infectious Disease 2026 ### Viral Immunity in Immunoglobulin Products, Global Immunity Debt and Autoimmunity Lindahl et al., 2026: viral immunity in IgG products and global immunity debt. Read paper ](/resources/viral-immunity-in-immunoglobulin-products-global-immunity-debt-and-autoimmunity)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/27722f6b8afb98376a851061d60b5b9f6b311cb7-1200x750.webp) Video MIPSA 2025 ### Management Blueprint Podcast: Simplify Complexity with Ben Larman Ben Larman on translating dense reactome data: Antibody Reactomics framework, Complex Data Delivery. Watch video ](/resources/management-blueprint-podcast-simplify-complexity-with-ben-larman)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication MIPSA 2024 ### Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn Dolphyn algorithm: efficient epitope prioritization for extensive antigenic spaces. Read paper ](/resources/efficient-encoding-of-large-antigenic-spaces-by-epitope-prioritization-with-dolp)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication MIPSA Vaccine Research 2024 ### Schistosoma mansoni vaccine candidates identified by unbiased phage display screening in self-cured rhesus macaques Schistosoma mansoni vaccine candidates identified via unbiased screening in self-cured macaques. Read paper ](/resources/schistosoma-mansoni-vaccine-candidates-identified-by-unbiased-phage-display-scre)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication HuSIGHT Oncology 2023 ### Coexisting autoantibodies against transcription factor Sp4 are associated with decreased cancer risk in patients with dermatomyositis with anti-TIF1γ autoantibodies Anti-Sp4 autoantibodies modify cancer risk in TIF1γ-positive dermatomyositis patients. Read paper ](/resources/coexisting-autoantibodies-against-transcription-factor-sp4-are-associated-with-d)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Biosurveillance 2023 ### Applications of VirScan to broad serological profiling of bat reservoirs for emerging zoonoses Antibody reactome profiling of bat reservoirs identifies emerging zoonotic potential for biosurveillance. Read paper ](/resources/applications-of-virscan-to-broad-serological-profiling-of-bat-reservoirs-for-eme)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Infectious Disease 2023 ### Comprehensive profiling of pre-infection antibodies identifies HIV targets associated with viremic control and viral load Frontiers Immunol 2023: pre-infection antibody reactome predicts post-infection HIV viral control. Read paper ](/resources/comprehensive-profiling-of-pre-infection-antibodies-identifies-hiv-targets-assoc)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Infectious Disease 2022 ### Comprehensive profiling of antibody responses to the human anellome using programmable phage display Antibody reactome profiling of the human anellome: small DNA viruses persisting in healthy hosts. Read paper ](/resources/comprehensive-profiling-of-antibody-responses-to-the-human-anellome-using-progra)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication MIPSA Allergy 2022 ### Allergenic food protein consumption is associated with systemic IgG antibody responses in non-allergic individuals Common food proteins drive systemic IgG responses in non-allergic adults (Cell Immunity, 2022). Read paper ](/resources/allergenic-food-protein-consumption-is-associated-with-systemic-igg-antibody-res)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication MIPSA 2022 ### Detecting antibody reactivities in Phage ImmunoPrecipitation Sequencing data Methods paper: statistical detection of true antibody reactivities in sequencing-based reactome data. Read paper ](/resources/detecting-antibody-reactivities-in-phage-immunoprecipitation-sequencing-data)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Vaccine Research 2022 ### Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells Females develop broader vaccine-induced antibody repertoires, driven by germinal-center B-cell diversity. Read paper ](/resources/greater-breadth-of-vaccine-induced-immunity-in-females-than-males-is-mediated-by)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication HuSIGHT Autoimmune 2022 ### Identification of Caveolae-Associated Protein 4 Autoantibodies as a Biomarker of Immune-Mediated Rippling Muscle Disease in Adults Anti-cavin-4 autoantibodies as a biomarker for immune-mediated rippling muscle disease. Read paper ](/resources/identification-of-caveolae-associated-protein-4-autoantibodies-as-a-biomarker-of)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication HuSIGHT MIPSA 2022 ### Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries Credle et al., Nature Comm 2022: the foundational MIPSA paper introducing antibody reactome profiling. Read paper ](/resources/unbiased-discovery-of-autoantibodies-associated-with-severe-covid-19-via-genome)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication HuSIGHT Autoimmune 2022 ### PhIP-Seq Reveals Autoantibodies for Ubiquitously Expressed Antigens in Viral Myocarditis Auto-antibody reactivities against ubiquitously expressed antigens identified in viral myocarditis cohort. Read paper ](/resources/phip-seq-reveals-autoantibodies-for-ubiquitously-expressed-antigens-in-viral-myo)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication EnviroSIGHT Biosurveillance 2022 ### Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses Antibody responses to environmental toxins and microbial virulence factors at population scale. Read paper ](/resources/phage-display-of-environmental-protein-toxins-and-virulence-factors-reveals-the)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Autoimmune 2022 ### Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis Bjornevik et al., Science 2022: 10M serial serum samples link EBV to multiple sclerosis. Read paper ](/resources/longitudinal-analysis-reveals-high-prevalence-of-epstein-barr-virus-associated-w)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT 2022 ### Analysis of antibody binding specificities in twin and SNP-genotyped cohorts reveals that antiviral antibody epitope selection is a heritable trait Antibody epitope selection is partially heritable, shown across twin and SNP-genotyped cohorts. Read paper ](/resources/analysis-of-antibody-binding-specificities-in-twin-and-snp-genotyped-cohorts-rev)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication MIPSA VirSIGHT 2022 ### Deconvoluting virome-wide antibody epitope reactivity profiles Bioinformatic deconvolution of cross-reactive signals in virome-wide antibody reactome data. Read paper ](/resources/deconvoluting-virome-wide-antibody-epitope-reactivity-profiles)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication MIPSA Allergy 2021 ### High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy Peanut OIT reshapes IgE and IgG epitope repertoires at single-epitope resolution. Read paper ](/resources/high-resolution-epitope-mapping-by-allerscan-reveals-relationships-between-ige-a)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication HuSIGHT Autoimmune 2021 ### Citrullination of a phage-displayed human peptidome library reveals the fine specificities of rheumatoid arthritis-associated autoantibodies Mapping anti-citrullinated protein antibody specificities in rheumatoid arthritis at single-epitope resolution. Read paper ](/resources/citrullination-of-a-phage-displayed-human-peptidome-library-reveals-the-fine-spe)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication HuSIGHT Oncology 2021 ### TGM4: an immunogenic prostate-restricted antigen TGM4: an immunogenic, prostate-restricted antigen and research target for prostate cancer. Read paper ](/resources/tgm4-an-immunogenic-prostate-restricted-antigen)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Infectious Disease 2021 ### SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy SARS-CoV-2 antibody signatures predict convalescent plasma antiviral function. Read paper ](/resources/sars-cov-2-antibody-signatures-robustly-predict-diverse-antiviral-functions-rele)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Infectious Disease 2021 ### Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality Pre-existing endemic coronavirus antibodies modulate COVID-19 convalescent plasma antiviral activity. Read paper ](/resources/antibody-responses-to-endemic-coronaviruses-modulate-covid-19-convalescent-plasm)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication MIPSA Allergy 2021 ### Profiling serum antibodies with a pan allergen phage library identifies key wheat allergy epitopes Wheat allergy IgE epitopes mapped at single-epitope resolution using a pan-allergen library. Read paper ](/resources/profiling-serum-antibodies-with-a-pan-allergen-phage-library-identifies-key-whea)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Infectious Disease 2021 ### HIV Antibody Profiles in HIV Controllers and Persons With Treatment-Induced Viral Suppression HIV controllers show distinct antibody reactome profiles compared to ART-suppressed individuals. Read paper ](/resources/hiv-antibody-profiles-in-hiv-controllers-and-persons-with-treatment-induced-vira)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Infectious Disease 2020 ### Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity Cross-reactive viral epitopes between SARS-CoV-2 and other coronaviruses, plus disease severity correlates. Read paper ](/resources/viral-epitope-profiling-of-covid-19-patients-reveals-cross-reactivity-and-correl)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Biosurveillance 2020 ### Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia Widespread dengue virus reactivity in bat populations across IndoMalaya and Australasia. Read paper ](/resources/robust-dengue-virus-infection-in-bat-cells-and-limited-innate-immune-responses-c)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication HuSIGHT Oncology 2020 ### LINE-1 ORF2p expression is nearly imperceptible in human cancers LINE-1 ORF2p protein expression is rare in human cancers, refining a long-held assumption. Read paper ](/resources/line-1-orf2p-expression-is-nearly-imperceptible-in-human-cancers)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Infectious Disease 2019 ### Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens Mina et al., Science 2019: measles infection erases antibody memory across the human virome. Read paper ](/resources/measles-virus-infection-diminishes-preexisting-antibodies-that-offer-protection)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Neurology 2019 ### Chronic Dengue Virus Panencephalitis in a Patient with Progressive Dementia with Extrapyramidal Features Chronic dengue virus identified as cause of unexplained progressive dementia (case report). Read paper ](/resources/chronic-dengue-virus-panencephalitis-in-a-patient-with-progressive-dementia-with)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Infectious Disease 2019 ### Comprehensive Profiling of HIV Antibody Evolution Tracking HIV-1 antibody co-evolution at single-epitope resolution across thousands of viral targets. Read paper ](/resources/comprehensive-profiling-of-hiv-antibody-evolution)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication MIPSA VirSIGHT 2015 ### Comprehensive serological profiling of human populations using a synthetic human virome (VirScan) Xu, Elledge et al., Science 2015: foundational paper on virome-wide antibody reactome profiling. Read paper ](/resources/comprehensive-serological-profiling-of-human-populations-using-a-synthetic-human)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication VirSIGHT Infectious Disease 2014 ### Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10 Tracing the developmental ontogeny of the broadly neutralizing anti-HIV antibody 4E10. Read paper ](/resources/ontogeny-of-recognition-specificity-and-functionality-for-the-broadly-neutralizi)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication HuSIGHT Autoimmune 2013 ### PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis Larman et al., 2013: foundational unbiased autoantibody discovery across MS, T1D, and RA. Read paper ](/resources/phip-seq-characterization-of-autoantibodies-from-patients-with-multiple-sclerosi)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication HuSIGHT Autoimmune 2013 ### Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis Anti-cN1A autoantibodies as a research-grade biomarker for sporadic inclusion body myositis. Read paper ](/resources/cytosolic-5-nucleotidase-1a-autoimmunity-in-sporadic-inclusion-body-myositis)[ ![](https://cdn.sanity.io/images/vbcbvda6/production/bd98a023e7b99b56fcec6d9b14b0ba00a1435f06-1200x750.webp) Publication HuSIGHT MIPSA 2011 ### Autoantigen discovery with a synthetic human peptidome Larman et al., Nat Biotech 2011: foundational synthetic human peptidome paper for autoantigen discovery. Read paper ](/resources/autoantigen-discovery-with-a-synthetic-human-peptidome)