Resources
Antibody Reactomics in Practice
Methodology, peer-reviewed evidence, and applications for scientists interested in adding antibody reactome profiling to their next big discovery.
Featured Resources
White Paper Unbiased analysis of antibody responses to all human viruses using Infinity Bio's VirSIGHT library
A peer-reviewed methodology white paper for VirSIGHT, Infinity Bio's unbiased antibody reactome assay covering 500+ human viruses from a single serum or CSF sample. Includes analytical validation (100% sensitivity against SARS-CoV-2, HIV-1, HSV1 reference cohorts), reproducibility across 6× replicate runs, and head-to-head benchmarking against PhIP-Seq on identical peptide sequences.
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Brochure Antibody Reactomics: The Responsive Layer of Immune Memory
Where the antibody reactome fits in the multi-omic stack, how MIPSA deciphers it, and what the HuSIGHT, VirSIGHT, and EnviroSIGHT libraries cover.
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Webinar Antibody Reactome Profiling for Human Health
Why reactome profiling captures biology that other immune assays miss.
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Webinar Antibody Reactome Profiling for Human Health
Why reactome profiling captures biology that other immune assays miss.
Video How measuring the reactivities of circulating antibodies through reactome profiling can provide novel insights into human health
Why reactome profiling captures biology that other immune assays miss.
Brochure HuSIGHT and EnviroSIGHT — InSIGHTs for Parkinson's Disease
HuSIGHT + EnviroSIGHT for Parkinson's research: environmental triggers and autoimmune contributions in one assay.
Video Unveiling the Antibody Reactome: A New Frontier in Precision Immunology
Antibody Reactomics: the new dimension for precision immunology research.
Podcast Antibody Reactome Profiling via self-assembling libraries of DNA barcoded antigens — AIRRC7
Ben Larman at AIRRC7: the science behind MIPSA library construction.
Video Infinity Bio MIPSA Explainer
How MIPSA deciphers the antibody reactome: the three-step workflow at a glance.
White Paper Unbiased analysis of antibody responses to all human viruses using Infinity Bio's VirSIGHT library
A peer-reviewed methodology white paper for VirSIGHT, Infinity Bio's unbiased antibody reactome assay covering 500+ human viruses from a single serum or CSF sample. Includes analytical validation (100% sensitivity against SARS-CoV-2, HIV-1, HSV1 reference cohorts), reproducibility across 6× replicate runs, and head-to-head benchmarking against PhIP-Seq on identical peptide sequences.
Brochure VirSIGHT InSIGHTs
VirSIGHT at a glance: antibody reactome profiling across the known human virome (500+ species).
Brochure Antibody Reactomics: The Responsive Layer of Immune Memory
Where the antibody reactome fits in the multi-omic stack, how MIPSA deciphers it, and what the HuSIGHT, VirSIGHT, and EnviroSIGHT libraries cover.
Publication Viral Immunity in Immunoglobulin Products, Global Immunity Debt and Autoimmunity
Lindahl et al., 2026: viral immunity in IgG products and global immunity debt.
Video Management Blueprint Podcast: Simplify Complexity with Ben Larman
Ben Larman on translating dense reactome data: Antibody Reactomics framework, Complex Data Delivery.
Publication Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn
Dolphyn algorithm: efficient epitope prioritization for extensive antigenic spaces.
Publication Schistosoma mansoni vaccine candidates identified by unbiased phage display screening in self-cured rhesus macaques
Schistosoma mansoni vaccine candidates identified via unbiased screening in self-cured macaques.
Publication Coexisting autoantibodies against transcription factor Sp4 are associated with decreased cancer risk in patients with dermatomyositis with anti-TIF1γ autoantibodies
Anti-Sp4 autoantibodies modify cancer risk in TIF1γ-positive dermatomyositis patients.
Publication Applications of VirScan to broad serological profiling of bat reservoirs for emerging zoonoses
Antibody reactome profiling of bat reservoirs identifies emerging zoonotic potential for biosurveillance.
Publication Comprehensive profiling of pre-infection antibodies identifies HIV targets associated with viremic control and viral load
Frontiers Immunol 2023: pre-infection antibody reactome predicts post-infection HIV viral control.
Publication Comprehensive profiling of antibody responses to the human anellome using programmable phage display
Antibody reactome profiling of the human anellome: small DNA viruses persisting in healthy hosts.
Publication Allergenic food protein consumption is associated with systemic IgG antibody responses in non-allergic individuals
Common food proteins drive systemic IgG responses in non-allergic adults (Cell Immunity, 2022).
Publication Detecting antibody reactivities in Phage ImmunoPrecipitation Sequencing data
Methods paper: statistical detection of true antibody reactivities in sequencing-based reactome data.
Publication Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells
Females develop broader vaccine-induced antibody repertoires, driven by germinal-center B-cell diversity.
Publication Identification of Caveolae-Associated Protein 4 Autoantibodies as a Biomarker of Immune-Mediated Rippling Muscle Disease in Adults
Anti-cavin-4 autoantibodies as a biomarker for immune-mediated rippling muscle disease.
Publication Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries
Credle et al., Nature Comm 2022: the foundational MIPSA paper introducing antibody reactome profiling.
Publication PhIP-Seq Reveals Autoantibodies for Ubiquitously Expressed Antigens in Viral Myocarditis
Auto-antibody reactivities against ubiquitously expressed antigens identified in viral myocarditis cohort.
Publication Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses
Antibody responses to environmental toxins and microbial virulence factors at population scale.
Publication Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Bjornevik et al., Science 2022: 10M serial serum samples link EBV to multiple sclerosis.
Publication Analysis of antibody binding specificities in twin and SNP-genotyped cohorts reveals that antiviral antibody epitope selection is a heritable trait
Antibody epitope selection is partially heritable, shown across twin and SNP-genotyped cohorts.
Publication Deconvoluting virome-wide antibody epitope reactivity profiles
Bioinformatic deconvolution of cross-reactive signals in virome-wide antibody reactome data.
Publication High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy
Peanut OIT reshapes IgE and IgG epitope repertoires at single-epitope resolution.
Publication Citrullination of a phage-displayed human peptidome library reveals the fine specificities of rheumatoid arthritis-associated autoantibodies
Mapping anti-citrullinated protein antibody specificities in rheumatoid arthritis at single-epitope resolution.
Publication TGM4: an immunogenic prostate-restricted antigen
TGM4: an immunogenic, prostate-restricted antigen and research target for prostate cancer.
Publication SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy
SARS-CoV-2 antibody signatures predict convalescent plasma antiviral function.
Publication Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality
Pre-existing endemic coronavirus antibodies modulate COVID-19 convalescent plasma antiviral activity.
Publication Profiling serum antibodies with a pan allergen phage library identifies key wheat allergy epitopes
Wheat allergy IgE epitopes mapped at single-epitope resolution using a pan-allergen library.
Publication HIV Antibody Profiles in HIV Controllers and Persons With Treatment-Induced Viral Suppression
HIV controllers show distinct antibody reactome profiles compared to ART-suppressed individuals.
Publication Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
Cross-reactive viral epitopes between SARS-CoV-2 and other coronaviruses, plus disease severity correlates.
Publication Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia
Widespread dengue virus reactivity in bat populations across IndoMalaya and Australasia.
Publication LINE-1 ORF2p expression is nearly imperceptible in human cancers
LINE-1 ORF2p protein expression is rare in human cancers, refining a long-held assumption.
Publication Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens
Mina et al., Science 2019: measles infection erases antibody memory across the human virome.
Publication Chronic Dengue Virus Panencephalitis in a Patient with Progressive Dementia with Extrapyramidal Features
Chronic dengue virus identified as cause of unexplained progressive dementia (case report).
Publication Comprehensive Profiling of HIV Antibody Evolution
Tracking HIV-1 antibody co-evolution at single-epitope resolution across thousands of viral targets.
Publication Comprehensive serological profiling of human populations using a synthetic human virome (VirScan)
Xu, Elledge et al., Science 2015: foundational paper on virome-wide antibody reactome profiling.
Publication Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10
Tracing the developmental ontogeny of the broadly neutralizing anti-HIV antibody 4E10.
Publication PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis
Larman et al., 2013: foundational unbiased autoantibody discovery across MS, T1D, and RA.
Publication Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis
Anti-cN1A autoantibodies as a research-grade biomarker for sporadic inclusion body myositis.
Publication Autoantigen discovery with a synthetic human peptidome
Larman et al., Nat Biotech 2011: foundational synthetic human peptidome paper for autoantigen discovery.